Inflammation is an essential part of the body’s healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune diseases.
Now, world-first genetic research from the University of South Australia has shown a direct link between low levels of vitamin D and high levels of inflammation, providing an important biomarker to identify people at higher risk of chronic illnesses with an inflammatory component.
The study examined the genetic data of 294 ,970 participants in the UK Biobank, using Mendelian randomization to show the association between vitamin D and C-reactive protein levels, an indicator of inflammation.
More D, less inflammation?
Lead researcher, UniSA’s Dr Ang Zhou, says the findings suggest that boosting vitamin D in people with a deficiency may reduce chronic inflammation.
‘Inflammation is your body’s way of protecting your tissues if you’ve been injured or have an infection,’ said Dr Zhou.
‘High levels of C-reactive protein are generated by the liver in response to inflammation, so when your body is experiencing chronic inflammation, it also shows higher levels of C-reactive protein.
‘This study examined vitamin D and C-reactive proteins and found a one-way relationship between low levels of vitamin D and high levels of C-reactive protein, expressed as inflammation.
‘Boosting vitamin D in people with deficiencies may reduce chronic inflammation, helping them avoid a number of related diseases,’ said Dr Zhou.
Supported by the National Health and Medical Research Council and published in the International Journal of Epidemiology, the study also raises the possibility that having adequate vitamin D concentrations may mitigate complications arising from obesity and reduce the risk or severity of chronic illnesses with an inflammatory component, such as cardiovascular diseases, diabetes, and autoimmune conditions.
Senior investigator and Director of UniSA’s Australian Centre for Precision Health, Professor Elina Hyppönen, says these results are important and provide an explanation for some of the controversies in reported associations with vitamin D.
‘We have repeatedly seen evidence for health benefits for increasing vitamin D concentrations in individuals with very low levels, while for others, there appears to be little to no benefit,’ said Professor Hyppönen.
‘These findings highlight the importance of avoiding clinical vitamin D deficiency, and provide further evidence for the wide-ranging effects of hormonal vitamin D,’ she said.